FcRn Binding Assay

The FcRn binding assay is a crucial analytical method for evaluating the interaction between the neonatal Fc receptor (FcRn) and IgG antibodies or Fc-fusion proteins. This assay is widely used in drug development to assess FcRn-mediated recycling and half-life extension of therapeutic antibodies. By measuring binding affinities under different pH conditions, researchers can optimize biologics for improved pharmacokinetics and efficacy. Selecting a sensitive and reliable FcRn binding assay ensures accurate characterization of antibody candidates, ultimately supporting the development of next-generation therapeutics.